Research
Research on Metabolic Syndrome
Metabolic Syndrome Canada is pleased to announce their study demonstrating metabolic syndrome (MetS) may be reversed through participation in a team-based lifestyle intervention program including diet and exercise changes is now published in CMAJ Open. Click here to access a PDF summary of the study.
Here is a link to our other published papers:
Impact of a multidisciplinary intervention on physical fitness, physical activity habits and the association between aerobic fitness and components of metabolic syndrome in adults diagnosed with metabolic syndrome. Click here for PDF version.
Nutrient intake and dietary quality changes within a personalized lifestyle intervention program for metabolic sydnrome in primary care. Click here for pdf version.
Patient experiences of a lifestyle program for metabolic syndrome offered in family medicine clinics
The CHANGE Program: Exercise Intervention in Primary Care. Click here to access a PDF version of the study.
Development of a Dietary Management Care Map for Metabolic Syndrome. Click here to access a PDF version of the study.
Metabolic syndrome and weight management programs in primary care: a comparison of three international healthcare systems. Click here to access a PDF version of the study.
Health professionals and researchers at Metabolic Syndrome Canada developed the CHANGE Program based on the best evidence from medical research. Below is an up-to-date collection of other studies related to metabolic syndrome published in leading journals, from the impact of diet and exercise to genetic determinants.
Metabolic Syndrome
Metabolic syndrome and chronic disease
Rao DP, et al. Chronic Diseases and Injuries in Canada. 2014 Feb;34(1):36-45.
Prevalence of metabolic syndrome in the Canadian adult population
Riediger ND, et al. Canadian Medical Association Journal. 2011 Oct 18; 183(15): e1127–e1134.
The metabolic fitness program: lifestyle modification for the metabolic syndrome using the resources of cardiac...
Rubenfire M, et al. Journal of Cardiopulmonary Rehabilitation and Prevention. 2011 Sep-Oct;31(5):282-9.
The impact of 3-year changes in lifestyle habits on metabolic syndrome parameters: The D.E.S.I.R study.
Balkau B, et al. European Journal of Cardiovascular Prevention & Rehabilitation. 2006 Jun;13(3):334-40.
Effect of a multifaceted, church-based wellness program on metabolic syndrome in 41 overweight or obese...
Ivester P, et al. Preventing Chronic Disease. 2010 Jul;7(4):A81.
Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation...
Alberti KG, et al. Circulation. 2009 Oct 20;120(16):1640-5.
The Reversal Intervention for Metabolic Syndrome (TRIMS) study: rationale, design, and baseline data.
Dunkley AJ, et al. Trials. 2011 May 4;12:107.
Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial.
Bo S, et al. The Journal of General Internal Medicine. 2007 Dec;22(12):1695-703.
Development of a Dietary Management Care Map for Metabolic Syndrome.
Royall D, et al. Canadian Journal of Dietetic Practice and Research. 2014;75(3):132-139.
The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: The diabetes prevention...
Orchard TJ, et al. Annals of Internal Medicine. 2005 Apr 19;142(8):611-9.
Toward a Unifying Hypothesis of Metabolic Syndrome.
Bremer Al, et al. Pediatrics. 2012 Mar 1;129(3):557-570.
Diet
Primary prevention of cardiovascular disease with a Mediterranean diet.
Estruch R, et al. New England Journal of Medicine. 2013 Apr 4;368(14):1279-90.
Adherence to a Mediterranean diet and survival in a Greek population.
Trichopoulou A, et al. New England Journal of Medicine. 2003 Jun 26;348(26):2599-608.
Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of...
Salas-Salvadó J, et al. Archives of Internal Medicine. 2008 Dec 8;168(22):2449-58.
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease.
de Lorgeril M, et al. Lancet. 1994 Jun 11;343(8911):1454- 9.
Mediterranean-style diet effect on the structural properties of the erythrocyte cell membrane of hypertensive...
Barceló F, et al. Hypertension. 2009 Nov;54(5):1143-50.
Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients...
Singh RB, et al. Lancet. 2002 Nov 9;360(9344):1455-61.
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results...
[no authors listed] Lancet. 1999 Aug 7;354(9177):447-55.
The relationship between dietary protein intake and blood pressure: Results from the PREMIER study.
Wang YF, et al. Journal of Human Hypertension. 2008 Nov;22(11):745-54
Effects of a stanol-enriched diet on plasma cholesterol and triglycerides in patients treated with statins.
Castro Cabezas M, et al. Journal of the American Dietetic Association. 2006 Oct;106(10):1564-9.
Long-term effects of ad libitum low-fat, high-carbohydrate diets on body weight and serum lipids in overweight...
Poppitt SD, et al. The American Journal of Clinical Nutrition. 2002 Jan;75(1):11-20.
The effect of dietary patterns on blood pressure control in hypertensive patients: Results from the dietary...
Conlin PR, et al. American Journal of Hypertension. 2000 Sep;13(9):949-55.
Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet.
Sacks FM, et al. New England Journal of Medicine. 2001 Jan 4;344(1):3-10.
Effect of a low glycemic index diet with soy protein and phytosterols on CVD risk factors in postmenopausal...
Lukaczer D, et al. Nutrition. 2006 Feb;22(2):104-13.
Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol.
Seppo L, et al. European Journal of Nutrition. 2007 Mar;46(2):111-7.
Additive effect of plant sterol-ester margarine and cerivastatin in lowering low-density lipoprotein...
Simons, LA. American Journal of Cardiology. 2002 Oct 1;90(7):737-40.
Lifestyle Intervention
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metaformin.
Knowler WC, et al. New England Journal of Medicine. 2002 Feb 7;346(6):393-403.
Comparative effectiveness of weight-loss interventions in clinical practice.
Appel LJ, et al. New England Journal of Medicine. 2011 Nov 24;365(21):1959-68.
Effectiveness of interventions for reducing diabetes and cardiovascular disease risk in people with metabolic...
Dunkley AJ, et al. Diabetes, Obesity and Metabolism. 2012 Jul;14(7):616-25.
Impact of 3-year lifestyle intervention on postprandial glucose metabolism: The SLIM study.
Roumen C, et al. Diabetic Medicine. 2008 May;25(5):597-605.
Effects of exercise and weight loss on cardiac risk factors associated with syndrome X.
Watkins LL, et al. Archives of Internal Medicine. 2003 Sep 8;163(16):1889-95.
Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults.
Villareal DT, et al. American Journal of Clinical Nutrition. 2006 Dec;84(6):1317-23.
Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older...
Shah K, et al. Obesity. 2009 Dec;17(12):2162-8.
Prevention of type II diabetes in subjects with impaired glucose tolerance: The diabetes prevention study (DPS)...
Eriksson J, et al. Diabetologia. 1999 Jul;42(7):793-801.
Substituting lifestyle management for pharmacological control of blood pressure: A pilot study in australian...
Reid CM, et al. Blood Pressure. 2000;9(5):267-74.
Non-pharmacological treatment of hypertension: Differences between health centres in patients' blood...
Tibblin G, Aberg H. Family Practice. 1990 Mar;7(1):47-51.
Exercise
Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in...
Perseghin G, et al. New England Journal of Medicine. 1996 Oct 31;335(18):1357-62.
Weight loss, exercise, or both and physical function in obese older adults.
Villareal DT, et al. New England Journal of Medicine. 2011 Mar 31;364(13):1218-29.
The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness
Ortega FB, et al. European Heart Journal. 2013 Feb;34(5):389-97.
Changes in multiple health outcomes at 12 and 24 weeks resulting from 12 weeks of exercise counseling with...
Melanson KJ, et al. Nutrition. 2004 Oct;20(10):849-56.
Exercise and weight loss reduce blood pressure in men and women with mild hypertension: Effects on cardiovascula...
Blumenthal JA, et al. Archives of Internal Medicine. 2000 Jul 10;160(13):1947-58
Supervised versus recommended physical exercise in hypertensive women. is its recommendation enough?
Bonet J, et al. Blood Pressure. 2003;12(3):139-44.
Moderate exercise improves glucose metabolism in uncontrolled elderly patients with non-insulin...
Raz I, et al. Israel Journal of Medical Sciences. 1994 Oct;30(10):766-70.
Baseline and previous physical activity in relation to mortality in elderly men: the Zutphen Elderly Study.
Bijnen FC, et al. American Journal Epidemiology. 1999 Dec 15;150(12):1289-96.
Strength training improves muscle quality and insulin sensitivity in hispanic older adults with type 2 diabetes.
Brooks N, et al. International Journal of Medical Sciences. 2006 Dec 18;4(1):19-27.
Increasing daily walking lowers blood pressure in postmenopausal women.
Moreau KL, et al. Medicine and Science in Sports and Exercise. 2001 Nov;33(11):1825-31.
Effects of exercise on body composition and functional capacity of the elderly.
Evans, WJ. Journals of Gerontology. 1995 Nov;50 Spec No:147-50.
The effect of a home-based walking program on risk factors for coronary heart disease in hypercholesterolaemic men...
Coghill N, Cooper AR. Preventive Medicine. 2008 Jun;46(6):545-51.
Brisk walking compared with an individualised medical fitness programme for patients with type 2 diabetes...
Praet SFE, et al. Diabetologia. 2008 May;51(5):736–746.
Promoting physical activity in a low-income multiethnic district: Effects of a community intervention study to...
Jenum AK, et al. Diabetes Care. 2006 Jul;29(7):1605-12.
Exercise training and nutritional supplementation for physical frailty in very elderly people.
Fiatarone MA, et al. New England Journal of Medicine. 1994 Jun 23;330(25):1769-75.
Genetic Determinants
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic...
Heid IM, et al. Nature Genetics. 2010 Nov;42(11):949-60.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Speliotes EK, et al. Nature Genetics. 2010 Nov; 42(11): 937–948.
FTO genotype and the weight loss benefits of moderate intensity exercise.
Mitchell JA, et al. Obesity. 2010 Mar;18(3):641-3.
Recent progress in the genetics of common obesity.
Loos RJ. British Journal of Clinical Pharmacology. 2009 Dec;68(6):811-29.
‘Fat mass and obesity associated’ gene (FTO): no significant association of variant rs9939609 with weight loss in a...
Müller TD, et al. BMC Medical Genetics. 2008 Sep 17;9:85.
Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise...
Ruaño G et al. Atherosclerosis. 2006 Mar;185(1):65-9.
Improved weight management using genetic information to personalize a calorie controlled diet.
Arkadianos I, et al. Nutrition Journal. 2007 Oct 18;6:29.
Family Practice and Lifestyle
Recommendations for prevention of weight gain and use of behavioural and pharmacologic interventions to...
Brauer P, et al. Canadian Medical Association Journal. 2015 Feb 17;187(3):184-95.
A novel approach to cardiovascular health by optimizing risk management (ANCHOR): behavioural modification...
Cox JL, et al. Canadian Journal of Cardiology. 2013 Nov;29(11):1400-7
Attitudes, norms and controls influencing lifestyle risk factor management in general practice.
Ampt AJ, et al. BMC Family Practice. 2009 Aug 26;10:59.
Identification and management of patients at elevated cardiometabolic risk in Canadian primary care: How well...
Teoh H, et al. Canadian Journal of Cardiology. 2013 Aug;29(8):960-8.